Shinichi Chiaki is a first class musician whose dream is to play among the elites in Europe. Coming from a distinguished family, he is an infamous perfectionist—not only is he highly critical of himself, but of others as well. The only thing stopping Shinichi from leaving for Europe is his fear of flying. As a result, he's grounded in Japan. During his fourth year at Japan's top music university, Shinichi happens to meet Megumi Noda or, as she refers to herself, Nodame. On the surface, she seems to be an unkempt girl with no direction in life. However, when Shinichi hears Nodame play the piano for the first time, he is in awe of the kind of music she creates. Nevertheless, Shinichi is dismayed to discover that Nodame is his neighbor, and worse, she ends up falling head over heels in love with him.

原作 XEBEC 総監督 能戸隆 監督 羽原信義 シリーズ構成 冲方丁 キャラクターデザイン 平井久司 メカニックデザイン 鷲尾直広 プロップデザイン 白井瑠子 色彩設定 関本美津子 美術監督 青木薫(美峰)（デザイン）、小濱俊裕(美峰) 撮影監督 青木隆 3D監督 井野元英二（CGIディレクター） 編集 伊藤潤一 音響監督 三間雅文 音楽 斉藤恒芳、ワルシャワ・フィルハーモニー管弦楽団 音楽制作 スターチャイルドレコード プロデューサー 中西豪（EXODUSはエグゼクティブP）、須藤孝太郎、橋本龍→亀井博司、丸山博雄（エグゼクティブP） アニメーション制作 XEBECzwei 製作 FAFNER EXODUS PROJECT、MBS

Tatsumiyajima is the central island in the middle of a small cluster of islands, in a sleepy backwater of the Japanese isles. Not much happens there, and the island's young people go to school knowing that their lives are likely to remain peaceful and undisturbed. Or so they have been taught...but the truth is different. The fate of mankind is on the line, and Tatsumiyajima is the last line of defense against a hostile and incomprehensible enemy. At the center of it all, fighting for Humanity's continued existence, is the giant robot Fafner, the dragon that guards this final treasure of mankind.

In the near future, humanity has taken its first steps towards journeying into the far reaches of the galaxy. Upon doing so they discover a huge race of insectoid aliens known as "Space Monsters." These aliens seem dedicated to the eradication of mankind as they near closer and closer to discovering Earth. In response, humanity develops giant fighting robots piloted by hand-picked youth from around the world. Shortly after the discovery of the aliens, Noriko Takaya, the daughter of a famous deceased space captain, enters a training school despite her questionable talents as a pilot. There, she meets her polar opposite, the beautiful and talented Kazumi Amano, and is unexpectedly made to work together with her as they attempt to overcome the trauma of war as well as their own emotions.

The war on terror exploded, literally, the day Sarajevo was destroyed by a homemade nuclear device. The leading democracies transformed into total surveillance states, and the developing world has drowned under a wave of genocides. The mysterious American John Paul seems to be behind the collapse of the world system, and it's up to intelligence agent Clavis Shepherd to track John Paul across the wreckage of civilizations and to find the true heart of darkness—a genocidal organ.

During the early 1930s in Chicago, the transcontinental train, Flying Pussyfoot, is starting its legendary journey that will leave a trail of blood all over the country. At the same time in New York, the ambitious scientist Szilard and his unwilling aide Ennis are looking for missing bottles of the immortality elixir. In addition, a war between the mafia groups is getting worse. On board the Advena Avis, in 1711, alchemists are about to learn the price of immortality.

In an alternate history where the male population is nearly decimated, eligible men serve as concubines to the woman shogun inside the walls of the Ooku.