Ramona is a little girl with a very big imagination and a nose for mischief. Her playful antics keep everyone in her loving family on their toes, including her older sister Beezus, who's just trying to survive her first year of high school. Through all the ups and downs of childhood, Ramona and Beezus learn that anything's possible when you believe in yourself and rely on each other.

Andrew returns to his hometown for the funeral of his mother, a journey that reconnects him with past friends. The trip coincides with his decision to stop taking his powerful antidepressants. A chance meeting with Sam - a girl also suffering from various maladies - opens up the possibility of rekindling emotional attachments, confronting his psychologist father, and perhaps beginning a new life.

Andy moves to New York to work in the fashion industry. Her boss is extremely demanding, cruel and won't let her succeed if she doesn't fit into the high class elegant look of their magazine.