A mosaic-style comedy following the life of a woman as time passes in her long-term casual BDSM relationship, low-level corporate job, and quarrelsome Jewish family.

After returning home from the Vietnam War, veteran Jacob Singer struggles to maintain his sanity. Plagued by hallucinations and flashbacks, Singer rapidly falls apart as the world and people around him morph and twist into disturbing images. His girlfriend, Jezzie, and ex-wife, Sarah, try to help, but to little avail. Even Singer's chiropractor friend, Louis, fails to reach him as he descends into madness.

Maggie is an alluring free spirit who won't let anyone – or anything – tie her down. But she meets her match in Jamie, whose relentless and nearly infallible charm serves him well with the ladies and the cutthroat world of pharmaceutical sales. Maggie and Jamie's evolving relationship takes them both by surprise, as they find themselves under the influence of the ultimate drug: love.

James White is a troubled twentysomething trying to stay afloat in a frenzied New York City. As he retreats further into a hedonistic lifestyle, his mother's battle with a serious illness faces a series of setbacks that force him to assume more responsibility. With the pressure on him mounting, James must find new reserves of strength or risk imploding completely.

Jessica, a Jewish copy editor living and working in New York City, is plagued by failed blind dates with men, and decides to answer a newspaper's personal advertisement. The advertisement has been placed by 'lesbian-curious' Helen Cooper, a thirtysomething art gallerist.

Virginia and Tony, a father and daughter living in Manhattan, find themselves in a parallel universe where Snow White, Cinderella and Little Red Riding Hood are struggling to maintain order. Their kingdoms have been fragmented by trolls, giants and goblins.

The life and career of shock-jock superstar Howard Stern is recounted from his humble beginnings to his view from the top. Possessing a desire to be an on-air personality since childhood, Stern meanders through the radio world, always with his supportive wife, Alison, by his side. Landing a gig in Washington, D.C., Stern meets Robin Quivers, who will become his long-time partner in crime. When the two move to New York, they face the wrath of NBC executives.

Two drug dealers on the lam seek refuge inside their mentally unstable friend’s mansion. But in order to stay, they have to participate in her elaborate, and increasingly dangerous, game of permanent make-believe.

Gia Carangi meteorically rises to modeling fame in the late 1970s but becomes overconsumed by persistent loneliness and drug addiction.

When her teenagers head off to camp and her husband abruptly leaves her to begin a new family, Lila is left to her own curious and chaotic devices for a summer in her rural home in the Catskill mountains.