While confronting the disapproving father of his girlfriend Lola, Native American man Willie Boy kills the man in self-defense, triggering a massive manhunt, led by Deputy Sheriff Christopher Cooper.

During a shootout in a saloon, Sheriff Hunt injures a suspicious stranger. The doctor's assistant, wife of the local foreman, tends to him in prison. That night, the town is attacked and they both disappear—only the arrow of a cannibal tribe is found. Hunt and a few of his men go in search of the prisoner and the foreman's wife.

Following the murder of her father by a hired hand, a 14-year-old farm girl sets out to capture the killer. To aid her, she hires the toughest U.S. Marshal she can find—a man with 'true grit'—Reuben J. 'Rooster' Cogburn.

As the west rapidly becomes civilized, a pair of outlaws in 1890s Wyoming find themselves pursued by a posse and decide to flee to South America in hopes of evading the law.

A mountain man who wishes to live the life of a hermit becomes the unwilling object of a long vendetta by Indians when he proves to be the match of their warriors in one-to-one combat on the early frontier.