Tampering with life and death, Henry Frankenstein pieces together salvaged body parts to bring a human monster to life; the mad scientist's dreams are shattered by his creation's violent rage as the monster awakens to a world in which he is unwelcome.

After a road accident in Hungary, the American honeymooners Joan and Peter and the enigmatic Dr. Werdegast find refuge in the house of the famed architect Hjalmar Poelzig, who shares a dark past with the doctor.