Heading through Colorado Territory in search of gold and women, Alferd Packer and his group of bemused companions find themselves lost, starving and musically inspired by the obstacles they confront along the way, including a die-hard Confederate cyclops, a trio of surly trappers, a tribe of Japanese-speaking "Indians," and ultimately, each other.

When a Black oil well worker is killed by a band of California neo-Nazis, his gun-wielding grandmother busts out of her retirement home to avenge him.