FBI agent Neville Flynn boards a flight from Honolulu, Hawaii to Los Angeles, escorting a key witness to testify against a mob boss at an upcoming trial. An on-board assassin releases a crate full of hundreds of deadly venomous snakes in an attempt to eliminate the witness. Flynn and a host of frightened passengers and crew must band together to survive the slithery threat.

A burger-loving hit man, his philosophical partner, a drug-addled gangster's moll and a washed-up boxer converge in this sprawling, comedic crime caper. Their adventures unfurl in three stories that ingeniously trip back and forth in time.

Samantha Caine is a small-town schoolteacher and mom with no memory of her life before washing up on a beach eight years ago. After a car accident and a violent home invasion trigger flashes of her past, she discovers she used to be a deadly CIA assassin. Teaming up with a wisecracking private investigator, Samantha must return to her old ways to take down the people who tried to erase her.

Death and violence anger twelve year old drug courier Fresh, who sets his rival employers against each other.