After an aging voodoo priestess dies, her arrogant son Willis Daniel's believes he is next in line to lead. He is outraged when Lisa, his mother's adopted apprentice is chosen as the leader. Willis seeks revenge by reviving the African prince Blacula — but soon finds that he cannot control him.

An 18th century African prince is turned into a vampire while visiting Transylvania. Two centuries later, he rises from his coffin attacking various residents of Los Angeles and meets Tina, a woman who he believes is the reincarnation of his deceased wife.