Two centuries in the future, when pollution has forced humans to abandon Earth in favor of cramped space stations, scientist Devon Adair hijacks a spacecraft and sets out with a band of followers in search of another planet that will offer a brighter, more normal future to children like her son, Ulysses. Joining Devon and Ulysses are mechanic John Danziger and his daughter, True; team physician Julia Heller, who has her own secret agenda; Alonzo Solace, a pilot; Yale, a cyborg; and Morgan, a craven government agent, and his wife, Bess. The voyagers find their planet, but their ship crash-lands on the wrong side of the globe, forcing them to attempt an arduous and dangerous trek to their ultimate destination, New Pacifica.

本剧改编自Emily St. John Mandel的同名小说。讲述世界因为灾难性流感而陷入末日，幸存者们则试图重建这个世界。

Based on one of the greatest video game series of all time, Fallout is the story of haves and have-nots in a world in which there’s almost nothing left to have. 200 years after the apocalypse, the gentle denizens of luxury fallout shelters are forced to return to the irradiated hellscape their ancestors left behind — and are shocked to discover an incredibly complex, gleefully weird and highly violent universe waiting for them.