The assorted humiliations, disasters and rare triumphs of four very different twenty-something girls: Hannah, an aspiring writer; Marnie, an art gallery assistant and cousins Jessa and Shoshanna.

Garfagnana, Italy, 1347. The handsome servant Masseto, fleeing from his vindictive master, takes shelter in a nunnery where three young nuns, Sister Alessandra, Sister Ginevra and Sister Fernanda, try unsuccessfully to find out what their purpose in life is, a conundrum that each of them faces in different ways.

Two college students, Frances and Bobbi, forge a strange and unexpected relationship with a married couple.

After graduating from film school, Aura returns to New York to live with her photographer mother, Siri, and her sister, Nadine, who has just finished high school. Aura is directionless and wonders where to go next in her career and her life. She takes a job in a restaurant and tries unsuccessfully to develop relationships with men, including Keith, a chef where she works, and cult Internet star Jed.