Jerry and his two pals, Russ and Syd, are just looking for some easy money to help them break out of their nowhere lives in their nowhere town. Despite a bungled jewelry store heist which exposes their incompetence as criminals, a fateful event (and an old black-and-white film) convinces them that they can pull off an armored-truck robbery. While they are busy plotting their caper, their dysfunctional families spin out of control, all around them.

Daryl Zero is a private investigator and—along with his assistant, Steve Arlo—he solves impossible crimes and puzzles. Although Daryl's a master investigator, he doesn't know what to do with himself when he's not working; he has no social skills, writes bad music and drives Steve crazy.

Suspicious that her colleague is responsible for a series of mysterious patient deaths, a nurse risks her own life to uncover the truth.