FBI agent Neville Flynn boards a flight from Honolulu, Hawaii to Los Angeles, escorting a key witness to testify against a mob boss at an upcoming trial. An on-board assassin releases a crate full of hundreds of deadly venomous snakes in an attempt to eliminate the witness. Flynn and a host of frightened passengers and crew must band together to survive the slithery threat.

Saturday Night Live aired its thirty-fifth season during the 2009–2010 television season on NBC. This season began on September 26, 2009 and ended on May 15, 2010.

A total of 22 episodes were broadcast during the show's eight-month-long season, which included a two-week break in February due to the 2010 Winter Olympics. The season was accompanied by three prime-time episodes of Saturday Night Live Weekend Update Thursday and three prime-time SNL clip shows.

Prior to the start of the season, many cast changes occurred. Darrell Hammond, the last cast member from the 1990s, left the show after a record 14 seasons in the cast. Featured players Michaela Watkins and Casey Wilson were both let go from the show before the start of the season.

To fill their absence the show brought in two new featured players, Nasim Pedrad and Jenny Slate. Abby Elliott and Bobby Moynihan continued as featured players.

A notable moment of the season was when an internet campaign was created to get actress Betty White to host an episode of the show. The campaign was started in early 2010 on Facebook and the group was called "Betty White to Host SNL!" The campaign was successful, and White became the oldest person ever to host the show. For White's episode, Lorne Michaels brought back former cast members Rachel Dratch, Tina Fey, Ana Gasteyer, Amy Poehler, Maya Rudolph and Molly Shannon. The episode garnered its highest ratings in over a year. with a rating of 5.8 in the 18–49 rating, demographic and with 12.1 million viewers overall.

Two gay men are possibly, probably, stumbling towards love. Maybe. They're both very busy.

Set in Chicago, the show follows the kid-friendly misadventures of two high-school friends who are always scheming and dreaming. Kenan, who works at a grocery store, constantly devises crazy plans to strike it rich, while orange-soda-loving buddy Kel is always dragged along for the ride despite his track record for messing things up.

High school loser pays a cheerleader to pose as his girlfriend so he can be considered cool.

The Grinch hatches a scheme to ruin Christmas when the residents of Whoville plan their annual holiday celebration.

After the patriarch of the Disguisey family is kidnapped by Devlin Bowman in an attempt to steal the most precious treasures from around the world, Italian waiter Pistachio Disguisey utilizes his supernatural ability to disguise himself in an attempt to stop him.

After one of his class papers is stolen and turned into a movie, a young student and his best friend exact a hilarious, slapstick revenge on the Hollywood hot shot who has taken credit!

After Gordon Bombay's hockey comeback is cut short he is named coach of Team USA Hockey for the Junior Goodwill Games. Bombay reunites the Mighty Ducks and introduces a few new players, however, he finds himself distracted by his newfound fame and must regather if the Ducks are to defeat tournament favourites Iceland.

The Ducks are offered scholarships at Eden Hall Academy but struggle with their new coach's methods and come under pressure from the board to retain their scholarships before their big game against the Varsity team.

A small business owner is about to lose her shop to a major corporate development.

Two L.A. teens with summer jobs at Good Burger try to save their small restaurant when a corporate giant burger franchise moves in across the street.

When Will Ferrell's good friend Harper comes out as a trans woman, they take a road trip to bond and reintroduce Harper to the country as her true self.

After being left at home by himself for the holidays, 10-year-old Max Mercer must work to defend his home from a married couple who tries to steal back a valuable heirloom.

Camp Hope is a summer retreat for overweight boys run by a kindly couple who make the campers feel comfortable with their extra pounds. But when tyrannical fitness guru Tony buys the camp, he puts the kids on a cruel regimen that goes too far. Sick of the endless weeks of "all work and no play," the kids stage a coup and reclaim their summer of fun.