Bob Hope is a stressed out talk show host who is sent on a vacation to Arizona on doctor's orders and has to play Sherlock Holmes with his wife, the lovely Eva Marie Saint, to solve a series of murders that has Bob as the prime suspect.

Insurance salesman Milford Farnsworth sells a man a life policy only to discover that the man in question is the outlaw Jesse James. Milford is sent to buy back the policy, but is robbed by Jesse. And when Jesse learns that Milford's boss is on the way out with more cash, he plans to rob him too and have Milford get killed in the robbery while dressed as Jesse, and collect on the policy.

Ronnie Jackson is a lowly baby photographer who secretly fantasizes about being a private detective. When a lovely baroness actually mistakes him for one and asks him to help locate her missing husband, Baron Montay, Ronnie finds himself agreeing. Several days later he is on death row whiling away the hours until his execution by recounting to a group of reporters the bizarre tale of how he ended up there.

Over fifty of the greatest living comedians are called to a party at Bob Hope's house, where each of them is systematically killed (and their bodies thrown in Hope's pool!). Hope and the rapidly shrinking cast try to discover who is the mysterious killer known only as "Joys."