Season 3 focused on Eleonora Sava. She lives with her older brother, completely independent from their parents, and prides herself on being wise beyond her years. However, her confidence threatens to come crashing down when she has to face her romantic feelings for Edoardo, a popular boy at school.

Season 4 focused on Sana Allagui, a Muslim-Italian girl. She begins to struggle to balance her faith and her friendships, as she begins to develop feelings for her brother's best friend, Malik.

Season 5 is the first to move past the original SKAM storylines, centering around Elia Santini. He struggles with toxic masculinity and sexual intimacy, as well as being forced to repeat his senior year of high school without his friends. Throughout the season, he finds himself drawn to classmate Viola.