NYPD detectives Bonaro and Madigan lose their guns to fugitive Barney Benesch. As compensation, they are given a weekend to bring Benesch to justice. While they follow various leads, Police Commissioner Russell goes about his duties, including attending functions, meeting with aggrieved relatives, and counseling the spouses of fallen officers.

When an in-flight collision incapacitates the pilots of an airplane bound for Los Angeles, stewardess Nancy Pryor is forced to take over the controls. From the ground, her boyfriend Alan Murdock, a retired test pilot, tries to talk her through piloting and landing the 747 aircraft. Worse yet, the anxious passengers — among which are a noisy nun and a cranky man — are aggravating the already tense atmosphere.