A group of self-absorbed actors set out to make the most expensive war film ever. After ballooning costs force the studio to cancel the movie, the frustrated director refuses to stop shooting, leading his cast into the jungles of Southeast Asia, where they encounter real bad guys.

Clear the runway for Derek Zoolander, VH1's three-time male model of the year. His face falls when hippie-chic Hansel scooters in to steal this year's award. The evil fashion guru Mugatu seizes the opportunity to turn Derek into a killing machine. It's a well-designed conspiracy and only with the help of Hansel and a few well-chosen accessories like Matilda can Derek make the world safe for male models everywhere.

Derek and Hansel are modelling again when an opposing company attempts to take them out from the business.