Chris Anderson and his wife Pam live a fairly normal life until Chris loses his job on the police force and secretly turns to robbing banks to make his wife's dreams come true. Upon discovering his secret, she joins his deadly crime wave and together they terrorize an unsuspecting suburban town.

Phil Weston has been unathletic his entire life. In college he failed at every sport that he tried out for. It looks like his 10-year old son, Sam, is following in his footsteps. But when Phil's hyper-competitive dad benches Sam, Phil decides to transfer his son to a new team which needs a coach. Phil steps in to be the temporary coach and immediately begins to butt heads with his dad over this new competition in their lives.

The season continued to focus on the surgical residency of five young interns as they try to balance to the challenges of their competitive careers, with the difficulties that determine their personal lives. It was set in the fictional Seattle Grace Hospital, located in the city of Seattle, Washington. Whereas the first season put the emphasis mainly on the unexpected impact the surgical field has on the main characters, the second one provides a detailed perspective on the personal background of each character, focusing on the consequences that their decisions have on their careers. Throughout the season, new story lines were introduced, including the love triangle between Meredith Grey, Derek Shepherd, and Addison Montgomery, the main arc of the season. Also heavily developed was the story line involving Izzie Stevens' relationship with patient Denny Duquette, which resulted in critical acclaim and positive fan response.