As Frank confronts his own mortality and family ties in his alcoholic and drug induced twilight years, Lip struggles with the prospect of becoming the family’s new patriarch. Newlyweds Ian and Mickey are figuring out the rules and responsibilities of being in a committed relationship while Deb embraces her individuality and single motherhood. Carl finds an unlikely new career in law enforcement and Kevin and V struggle to decide whether a hard life on the South Side is worth fighting for.

新季由来自《善地》的William Jackson Harper担任主演。他将饰演Marcus Watkins刚和一个本以为会是自己真爱的女人，结束了一段多年的关系。突然爱情失意的他，重新开始寻找属于自己的另一半。
第一季回归客串的卡司有Anna Kendrick、Zoë Chao、Peter Vack和Nick Thune。