After her much older husband forces a move to a suburban retirement community, Pippa Lee engages in a period of reflection and finds herself heading toward a quiet nervous breakdown.

Catherine is a woman in her late twenties who is strongly devoted to her father, Robert, a brilliant and well-known mathematician whose grip on reality is beginning to slip away. As Robert descends into madness, Catherine begins to wonder if she may have inherited her father's mental illness along with his mathematical genius.

Maggie's plan to have a baby on her own with a sperm donor is derailed when she falls in love with John, an older married professor, destroying his volatile marriage to the brilliant and impossible Georgette. But three years later, married to John with one daughter, Maggie is out of love and in a quandary: what do you do when you suspect your man and his ex-wife are actually perfect for each other?