Jana Ackermans is the central character and the season focuses on her relationship with her boyfriend Jens as well as themes of loneliness, identity, and friendship.

Zoë Loockx is the central character and the season focuses on her relationship with Senne, a popular boy at school, and themes of friendship, self-image, and sexual abuse.

Robbe IJzermans is the central character and the season focuses on his coming out as gay and his relationship with Sander, who struggles with bipolar disorder. It also deals with themes of sexual identity, homosexuality, and mental health.

The series diverged from the original SKAM storyline with a new character, Kato Fransen. The storyline deals with social media, racism, self-harm, drugs, and COVID-19.

Yasmina Ait Omar is the central character, with the season focusing on ideas of faith and religion, being Muslim in Belgium, and the holy month of Ramadan.