Robert Neville is a scientist who was unable to stop the spread of the terrible virus that was incurable and man-made. Immune, Neville is now the last human survivor in what is left of New York City and perhaps the world. For three years, Neville has faithfully sent out daily radio messages, desperate to find any other survivors who might be out there. But he is not alone.

Madeline has become an integral part of a prestigious physical theater troupe. When the workshop's ambitious director pushes the teenager to weave her rich interior world and troubled history with her mother into their collective art, the lines between performance and reality begin to blur. The resulting battle between imagination and appropriation rips out of the rehearsal space and through all three women's lives.

Agatha Harkness gathers a coven of witches and sets off down, down, down The Witches' Road.

After Silvia Broome, an interpreter at United Nations headquarters, overhears plans of an assassination, an American Secret Service agent is sent to investigate.

Since his wife's death, Victor has raised his daughter Angela alone. After she and her friend return from a three-day disappearance with missing memories, they begin displaying frightening behavior reminiscent of the MacNeil possession fifty years prior.

In the aftermath of her husband's death, widow Ramona's struggle to raise her two kids is hindered by the arrival of a mysterious woman with supernatural abilities.