Ruthless Italian-American banker Gino Monetti is engaged in a number of criminal activities. Three of his four grown sons refuse to help their father stay out of prison after he's arrested for his questionable business practices. Three of them take over the business but kick their father out. Max, a lawyer, is the only son that remains loyal.

When an in-flight collision incapacitates the pilots of an airplane bound for Los Angeles, stewardess Nancy Pryor is forced to take over the controls. From the ground, her boyfriend Alan Murdock, a retired test pilot, tries to talk her through piloting and landing the 747 aircraft. Worse yet, the anxious passengers — among which are a noisy nun and a cranky man — are aggravating the already tense atmosphere.