A New York City newspaper is sued for libel after reporting the wrong verdict in a murder trial.

Twelve people are aboard Coast Airline's flagship the Silver Queen enroute to South America when the airplane encounters a storm and is blown off course. Crashing into jungles known to be inhabited by head hunters, pilots Bill and Joe race against time to fix the engines and attempt a take off. The situation brings out the best and worst in the stranded dozen as they create a makeshift runway and prepare to escape before the natives attack. But damage to the plane and low fuel reserves means that only 5 people can be carried to safety.

George Sanders makes his final appearance as crook-turned-detective Simon Templar, a.k.a. "The Saint," in The Saint in Palm Springs. The gimmick in this one is a set of rare stamps, smuggled from England. Wendy Barrie is the true heir to this treasure, and the Saint is engaged to protect her and the stamps. Our hero meets Barrie in a posh Palm Springs resort, where a gang of homicidal thieves have converged to relieve the girl of her inheritance. Three murders and one kidnapping attempt later, the villains are foiled by the Saint, with the aid of his onetime partner in crime Pearly Gates (Paul Guilfoyle). The Saint in Palm Springs is the sixth in RKO's series of films based on the character created by Leslie Charteris.

Set during Prohibition, the movie centers on Touhy's rise from small time thug to the city's most powerful bootlegger whose empire is rivaled only by that of Al Capone (who is referred to, but never named in the story). It is his rival who frames Touhy for kidnapping and arranges for him to serve a life-long term in Stateville prison. Determined to be free again, the desperate Touhy and his cellmate Basil "the Owl" Banghart, begin plotting a violent break out.

After serving five years of a life sentence, Rocky Mulloy hopes to clear his friend who's still in prison for the same crime.