Two married couples find only trouble and heartache as their complicated lives unfold. After 40 years of marriage, Alfie leaves his wife to pursue what he thinks is happiness with a call girl. His wife, Helena, reeling from abandonment, decides to follow the advice of a psychic. Sally, the daughter of Alfie and Helena, is unhappy in her marriage and develops a crush on her boss, while her husband, Roy, falls for a woman engaged to be married.

Max Lowe is a Houston surgeon who has grown weary of the bureaucracy of American medicine. When he loses a patient on the operating table, Max impulsively decides to leave America and travel to India in the hope of finding himself. Not long after he arrives in Calcutta, Max is attacked by a group of thugs and left without money or a passport.