Handsome Stranger has agreed to escort Charming Jones to collect her inheritance from her father. But Avery Simpson wants the money and hires notorious outlaw Cactus Jack to ambush Charming. However, Cactus Jack is not very good at robbing people.

Over fifty of the greatest living comedians are called to a party at Bob Hope's house, where each of them is systematically killed (and their bodies thrown in Hope's pool!). Hope and the rapidly shrinking cast try to discover who is the mysterious killer known only as "Joys."