The lives and loves behind the scenes at the racetrack are detailed in this thoroughbred soap opera. An ambitious young trainer, Joel Tarrant (Ty Hardin), enters into an illicit affair with the stable owner's wealthy wife, hot-to-trot Laura Rubio (Suzanne Pleshette), in the hope that someday he'll have enough dough to buy his own horses and stable.

A group of unlikely travelling companions find themselves on the same stagecoach to Cheyenne. They include a drunken doctor, a bar girl who's been thrown out of town, a professional gambler, a travelling liquor salesman, a banker who has decided to embezzle money, a gun-slinger out for revenge and a young woman going to join her army captain husband. All have secrets but when they are set upon by an Indian war party and then a family of outlaws, they find they must all work together if they are to stay alive.

Jack Diamond and his sickly brother arrive in prohibition New York as jewelry thieves. After a spell in jail, the coldly ambitious Diamond hits on the idea of stealing from thieves himself and sets about getting close to gangster boss Arnold Rothstein to move in on his booze, girls, gambling, and drugs operations.