An abortion clinic worker with a special heritage is called upon to save the existence of humanity from being negated by two renegade angels trying to exploit a loophole and reenter Heaven.

Convenience and video store clerks Dante and Randal are sharp-witted, potty-mouthed and bored out of their minds. So in between needling customers, the counter jockeys play hockey on the roof, visit a funeral home and deal with their love lives.

When Jay and Silent Bob learn that their comic-book alter egos, Bluntman and Chronic, have been sold to Hollywood as part of a big-screen movie that leaves them out of any royalties, the pair travels to Tinseltown to sabotage the production.

A calamity at Dante and Randall's shops sends them looking for new horizons - but they ultimately settle at Mooby's, a fictional Disney-McDonald's-style fast-food empire.

After narrowly surviving a massive heart attack, Randal enlists his old friend Dante to help him make a movie immortalizing their youthful days at the little convenience store that started it all.

Lifelong platonic friends Zack and Miri look to solve their respective cash-flow problems by making an adult film together. As the cameras roll, however, the duo begin to sense that they may have more feelings for each other than they previously thought.