This movie tells five stories set in a single day at the famed Chelsea Hotel in New York City, involving an ensemble cast of some 30-35 characters.

The death of a friend galvanizes three high school young women to reassess their friendship and their lives.

A mob enforcer is set up to take the fall for a multi-million dollar heist involving a rival gang boss. Merle (Eric Roberts) is a gambler stuck on a twenty-year losing streak, but his luck is about to change. Surviving a trap that was intended to kill him, Merle makes away with a beautiful woman and a piece of the take. Most men in that position would have been content to simply walk away with their lives, but Merle has been loyal for twenty years. Realizing he's been betrayed, something inside snaps. They used to call him "The Butcher" as a joke, but the laughter turns to screams when Merle returns to deliver the ultimate punchline.

Richard Clark has just left the well-known Wellington Academy to teach at Marion Barry High School. Now, he will try to inspire the D-average students into making good grades and try to woo a fellow teacher.

After Majestic gets burned to the ground, Nancy relocates her family to Ren Mar to set up shop and partners with Guilermo and his Boss, Esteban. Knowing she has nothing, Celia moves to Ren Mar to start over, but begins developing a surprising problem. Shane begins to embrace a dark side of himself. Silas and Doug decide to open up a medicinal marijuana store.

In 1981 New York City, a collection of twentysomethings try to cope with relationships, loneliness, desire and their individual neuroses on New Years Eve.