Over the course of ten days and 435 miles, an unbreakable bond is forged between pro adventure racer Michael Light and a scrappy street dog companion dubbed Arthur. As the team is pushed to their outer limits of endurance in the race, Arthur redefines what victory, loyalty and friendship truly mean.

In 1900, the surgeons and nurses at the Knickerbocker Hospital in New York push the boundaries of medicine in a time of high mortality rates and zero antibiotics. Chief surgeon Dr. John Thackery pioneers new methods in the field while harboring a severe cocaine addiction.