In an isolated family mansion, a group of rich 20-somethings decides to play Bodies Bodies Bodies, a game where one of them is secretly a "killer" while the rest tries to "escape". Things take a turn for the worse when real bodies start turning up, setting off a paranoid and dangerous chain of events.

When carefree Nyles and reluctant maid of honor Sarah have a chance encounter at a Palm Springs wedding, things get complicated when they find themselves unable to escape the venue, themselves, or each other.