Earth is visited by an alien species that threatens humanity's existence. Events unfold in real time through the eyes of five ordinary people across the globe as they struggle to make sense of the chaos unraveling around them.

It's 1946, and peace has dealt Peggy Carter a serious blow as she finds herself marginalized when the men return home from fighting abroad. Working for the covert SSR (Strategic Scientific Reserve), Peggy must balance doing administrative work and going on secret missions for Howard Stark all while trying to navigate life as a single woman in America, in the wake of losing the love of her life - Steve Rogers.

Echo is a member of a highly illegal and underground group of individuals whose personalities have been wiped clean so they can be imprinted with any number of new personas. Confined between missions to a secret facility known as the Dollhouse, the "Actives" are hired by the wealthy, powerful and connected to wholly become—with mind, personality and physiology—whomever the client wants or needs them to be. They know no other life than the specific engagements they are in at that time—or do they?