Billie Holiday spent much of her career being adored by fans. In the 1940s, the government targeted Holiday in a growing effort to racialize the war on drugs, ultimately aiming to stop her from singing her controversial ballad, "Strange Fruit."

Mikey and Rose are professional assassins. They are also lovers, and once upon a time Rose also knew Mikey's father. During an elaborate hit job for a malicious gangster, Rose fails to kill the main target, the gangster's pregnant girlfriend. Instead, she delivers her baby and convinces Mikey to help her protect them both. As Rose weakens from cancer, Mikey becomes breadwinner for this unusual family. But tranquility will not last.