Spartacus, determined to bring down the Roman Republic, now leads a rebellion swelled by thousands of freed slaves. Roman leader Gaius Claudius Glaber has died, and former rivals Naevia, Crixus, Gannicus and Agron become rebel generals, joining Spartacus in the war against the empire. The Roman Senate turns to a ruthless politician and soldier, Marcus Crassus, to put down the slaves. Crassus takes on a young rising star - Julius Caesar - as an ally.

When a terrorist bomb destroys a building in Dallas, Texas FBI agents Fox Mulder and Dana Scully are drawn into a dangerous conspiracy surpassing anything they’ve ever encountered. With the dubious assistance of a paranoid doctor, Mulder and Scully risk their careers and their lives to hunt down a deadly virus which may be extraterrestrial in origin — and could destroy all life on Earth.

As Mulder lies in a neurological unit, his brain under attack by a deadly onslaught of electrical impulses, Scully struggles to decipher strange symbols covering a spacecraft found submerged off West Africa's Ivory Coast. But the connection between these two phenomena is just the first of many challenges the agents are destined to confront. For they are about to enter a time of closure and a time of new beginnings. For Mulder there's the death of his mother and Diana Fowley, and the end of his search for his abducted sister, Samantha. For Scully it is a time to face her own personal demons, among them the return of death fetishist Donnie Pfaster. Yet just as Scully faces the ultimate new beginning, the ultimate horror occurs — the abduction of Mulder.

After Mulder’s disappearance, Scully returns to FBI headquarters to find Special Agent John Doggett heading up a FBI manhunt for her partner. Knowing that type of search will prove futile, Scully and Skinner turn to the Lone Gunmen in hopes of uncovering information about additional UFO activity around the time of Mulder’s disappearance. Although such information leads them to Gibson Praise, the man with Gibson, a man who appears to be Mulder, is in fact an alien bounty hunter. Finally realizing that Mulder will not be found so easily, Agent Doggett is officially assigned to the X-Files. Now, after all she has been through with Mulder, it is Scully who is “the believer” and who must find a way to work with “the skeptic,” John Doggett.