When the groom's oldest friend, Cole, finds out his best friend, Jason, is getting married, he escapes from the institution he has been incarcerated in and makes a surprise visit to serve as the best man. Something does not seem right between bride, Gretchen, and groom. None of their friends seem to fully support the marriage and have secrets of their own. Unresolved about their relationship and endlessly obsessed with the groom, Cole stirs up everyone and everything, making it a weekend to remember.

Miranda Priestly navigates her career amid the decline of traditional magazine publishing. She faces off against Emily Charlton, her one-time assistant, now a high-powered executive for a luxury group, with advertising dollars that Priestly desperately needs.