Four friends, annoyed at how almost everyone else they know is having sex but them, agree to do what they can to help each other lose their virginity before the end of the summer. Most of their opportunities are foiled by their inexperience and bad planning. Michael, the most sensible boy of the foursome, really just wants to stay with his long-time girlfriend and take their relationship to an intimate level, but after putting him off for six months he grows impatient and splits up with her to seek his fortune elsewhere.

When a dispute occurs between a logging operation and a nearby Native American tribe, Dr. Robert Verne and his wife, Maggie, are sent in to mediate. Chief John Hawks insists the loggers are poisoning the water supply, and, though company man Isley denies it, the Vernes can't ignore the strangely mutated wildlife roaming the woods. Robert captures a bear cub for testing and soon finds himself the target of an angry mutant grizzly.