Kaiji Ito moves to Japan after graduating from high school. Unable to find a job and frustrated with society at large, Kaiji spends his days gambling, vandalizing cars, and drinking booze. Two years later and his life is no better. A debt collector named Endo arrives to collect money owed. The debt collector offers two choices to Kaiji: spend 10 years paying off his loan or board a gambling boat for one night to repay his debt & possibly make a boat load of money. Could the debt collector Endo actually be setting up Kaiji? One way or another, for Kaiji it's going to be the night of his life.

3 years after the ultimate life-or-death game with Teiai Group, Kaiji was entrapped by Teiai and again back in the underground, forced to do hard labour. One day, Kaiji wins a bet to get out of the underground with 1 million yen, and promises the other workers that he will save them. But to do so, he only has 14 days and needs 200 million yen! Kaiji meets his former rival Tonegawa and learns that there is a chance to turn the tables in the game. It was a monster casino machine that will make 1 billion yen if you win...

为了应对多样化的现代犯罪，警视厅从各部门抽调在犯罪心理学、化学分析、弹痕学等方面卓有成效的几名研究人员，成立了简称为ST的科学特搜班。ST的主要成员为青山翔（志田未来 饰）、结城翠（芦名星 饰）、黑崎勇治（漥田正孝 饰）、山吹才藏以及似乎患有人类恐惧症闭门不出的队长赤城左门（藤原龙也 饰）。这群人专业出众，个性鲜明，怪癖十足，遭致警局上下讨厌而不自知。由于赤城缺席，因为偷税被降职为ST的指挥官百合根友久（冈田将生 饰）只得想尽办法协调ST和搜查本部的关系。一起无差别杀人案，带领ST走入迷雾重重的犯罪漩涡。扑朔迷离的前路，ST的各位无畏前行……
本片根据今野敏的原作改编。

Hisako loses her home in Tokyo to Allied bombing. With her husband fighting somewhere in Asia, she and her two children evacuate to a suburb of Kobe, where they share a house with Hisako's cousin, Kyoko. Kobe is bombed and Kyoko is killed. Hisako is forced to take care of Kyoko's two children in addition to her own, but there is not enough food for everyone.