Steve McGarrett returns home to Oahu, in order to find his father's killer. The governor offers him the chance to run his own task force (Five-0). Steve's team is joined by Chin Ho Kelly, Danny "Danno" Williams, and Kono Kalakaua.

A year after a supermoon’s light activated a dormant gene, transforming humans into bloodthirsty werewolves and causing nearly a billion deaths, the nightmare resurfaces as the supermoon rises again. Two scientists attempt to stop the mutation but fail and must now struggle to reach one of their family homes.