Django arrives in the town of Santa Anna at the behest of a man named Sanders who'd been trying to buy safe passage for his cargo from a Mexican bandit named El Santo. Django finds that Sanders has been killed and that his rival, a man named Thompson, is now trying to deal with El Santo. Django, after a brief involvement with a beautiful young widow named Linda -- who has information on a lost gold mine -- becomes entangled in this situation by agreeing to escort a shipment through El Santo's territory.

A man is falsely charged with bank robbery, prompting his brother to break him out of prison. Together the pair set out to find the real culprits, and their search leads them to a gang of outlaws headed by a notorious gunfighter.