The assorted humiliations, disasters and rare triumphs of four very different twenty-something girls: Hannah, an aspiring writer; Marnie, an art gallery assistant and cousins Jessa and Shoshanna.

Sarah Jo is a naive 26-year-old living on the fringes of Hollywood with her mother and sister. When she begins an affair with her older employer, she is thrust into an education on sexuality, loss and power.

The cutthroat world of international finance is seen through the eyes of a talented outsider fighting to prove her worth. Harper Stern, a determined young woman, finds herself among a group of enterprising young graduates vying to secure their futures at Pierpoint & Co., a leading bank in London.

After spending a decade in a failed relationship, successful couples’ therapist Ally is turning 40 and is pushed, kicking and screaming, by her best friend back into the hopeless New York dating scene. But Ally finds her life pulled in opposing directions as she falls into a steamy fling with a 20-something Brooklyn hipster just as she begins a promising, more conventional relationship with Alan, a successful 50-something in Manhattan.

After graduating from film school, Aura returns to New York to live with her photographer mother, Siri, and her sister, Nadine, who has just finished high school. Aura is directionless and wonders where to go next in her career and her life. She takes a job in a restaurant and tries unsuccessfully to develop relationships with men, including Keith, a chef where she works, and cult Internet star Jed.