This drama is an updated version of Ulmer's 1944 film Bluebeard. It is set in New York and follows the exploits of an eccentric Parisian painter who has come to New York to escape a controversy surrounding his work. The trouble stems when the model he has used in all his work is found floating dead in the Seine.

The story of Dr. Charles Randolph, a scientist dedicated to deciphering the secrets of life and death. Aided by assistant David Cochran, Charles conducts experiments that have horrifying side effects. Charles's lonely wife, Elaine, is frightened by his work, and in order to protect her, housekeeper Maria unleashes a torrent of voodoo that wrecks havoc.