In Cameron, a group of hunters is attacked by a wild animal, and Charlie Cowley survives, but sees his brother Scott dying. Seven years later, his teenage nephew Derek Cowley steals the key of his stepfather's cabin in the isolated Fire Road 13, and travels with four classmates and his friend Sam to spend the weekend having a party with booze and sex. However, they are attacked by a Beast that kills his friends in a sadistic way. Sam and Derek survive, and they suspect that his stepfather, Mitchell Toblat, is a werewolf. When Charlie meets Derek and Sam, they decide to collect evidence to prove that Mitchell is the Beast and kill him, but Mitchell discovers their plot and chases the trio.

Uptight lawyer Peter Sanderson wants to dive back into dating after his divorce and has a hard time meeting the right women. He tries online dating and lucks out when he starts chatting with a fellow lawyer. The two agree to meet in the flesh, but the woman he meets — an escaped African-American convict named Charlene — is not what he expected. Peter is freaked out, but Charlene tries to convince him to take her case and prove her innocence. Along the way, she wreaks havoc on his middle-class life as he gets a lesson in learning to lighten up.