Pilgrim Corporation has leased Choke Canyon to research physicist David Lowell for 99 years. Lowell has built an impressive research laboratory there. When Pilgrim suddenly needs Choke Canyon for toxic waste storage, they resort to violence to force out the renitent Lowell. However, Pilgrim Corportation vastly underestimates Lowell, who is a tenacious, principled, and ingenious man.

When fellow operatives and friends disappear during a mission in Hong Kong, Cleopatra Jones comes to help. She discovers the disappearance involves The Dragon Lady, a feared lipstick lesbian who runs a casino and the local drug trade.