Shinichi Koga, known as a leading figure in supernatural manga, takes on one of his best known creations. When a crisis occurs at Misonogaoka High School, students falling prey to black magic, a teenage girl, (a witch herself), steps in to help. Misa Kuroi, attempts to rescue her fellow classmates by battling the dark forces with magic that has been passed down in her family for generations. But when her parents are mummified, can Misa battle on her own?

In Meiji-era Japan, a village of witches and wizards is slaughtered. Years later, an archaeologist discovers a mummy from the village, which reanimates, murders, then possesses his assistant. This evil spirit is now searching for Misa, who is protected by a survivor of the original massacre, known only as Saiga.