Times are changing for Manny the moody mammoth, Sid the motor mouthed sloth and Diego the crafty saber-toothed tiger. Life heats up for our heroes when they meet some new and none-too-friendly neighbors – the mighty dinosaurs.

Set after the events of Continental Drift, Scrat's epic pursuit of his elusive acorn catapults him outside of Earth, where he accidentally sets off a series of cosmic events that transform and threaten the planet. To save themselves from peril, Manny, Sid, Diego, and the rest of the herd leave their home and embark on a quest full of thrills and spills, highs and lows, laughter and adventure while traveling to exotic new lands and locations.

Manny, Diego, and Sid embark upon another adventure after their continent is set adrift. Using an iceberg as a ship, they encounter sea creatures and battle pirates as they explore a new world.

With the impending ice age almost upon them, a mismatched trio of prehistoric critters – Manny the woolly mammoth, Diego the saber-toothed tiger and Sid the giant sloth – find an orphaned infant and decide to return it to its human parents. Along the way, the unlikely allies become friends but, when enemies attack, their quest takes on far nobler aims.

Sid the Sloth takes a school of children out on a camping trip from home, only to find that in typical Sid style, he is not a very good guide and the children he takes with him don't have a very good time.

Scrat tries to finish his rather large collection of acorns when things start going nutty.

Rodney Copperbottom is a young robot inventor who dreams of making the world a better place, until the evil Ratchet takes over Big Weld Industries. Now, Rodney's dreams – and those of his friends – are in danger of becoming obsolete.

Scrat experiences the ups and downs of fatherhood, as he and the adorable, mischievous Baby Scrat, alternately bond with each other and battle for ownership of the highly treasured Acorn.