Dr. Malcolm Sayer, a shy research physician, uses an experimental drug to "awaken" the catatonic victims of a rare disease. Leonard is the first patient to receive the controversial treatment. His awakening, filled with awe and enthusiasm, proves a rebirth for Sayer too, as the exuberant patient reveals life's simple but unutterably sweet pleasures to the introverted doctor.

At an elite, old-fashioned boarding school in New England, a passionate English teacher inspires his students to rebel against convention and seize the potential of every day, courting the disdain of the stern headmaster.

Léon, the top hit man in New York, has earned a rep as an effective "cleaner". But when his next-door neighbors are wiped out by a loose-cannon DEA agent, he becomes the unwilling custodian of 12-year-old Mathilda. Before long, Mathilda's thoughts turn to revenge, and she considers following in Léon's footsteps.