Benoit Blanc loves living, he loves women, he loves daring. He is a famous businessman who suffers from stomach-ache. Fabiolini, a would-be actor, is a policeman and he too suffers from the same sickness. The two man face suffering in opposite ways: Benoit Blanc is optimistic while Fabiolini, always unsure of himself, is persuaded he is seriously ill. The two men meet by chance while doing a gastroscopy and become friends. After having known their real different conditions, they will change and will understand better their lives. Around them, other people, women and men, will see their lives changed, by chance, by love or solely by the life stream.

When odd reports are received through official channels stating that the President of the United States is being held captive on a secret international moon base called Vegan and that he has been replaced on Earth by a clone, the US Marshall Service immediately sends their 'best' man, Dix, on the mission.