Jesse James returns to Missouri, and he and brother Frank come to the aid of a young woman who owns a gold mine. Her father was murdered and she took over the mine, and now the villains who killed her father are trying to drive her out of the mine so they can take it over.

The female leader of an international crime ring steals a valuable artifact that can give her the power to control men's minds. Federal agents are dispatched to get it back and stop her evil plans.