Penfield Gruber, a once great scientist, is reduced to managing a sleazy hotel. He monitors the daily comings and goings of his tenants, mainly for his own interest, until underworld figures ask him to spy on a suspected double-crosser. While watching the man, Gruber overhears a murder plot.

When a law student accidentally kills the son of a mob boss in a fight, he finds himself relentlessly pursued by the mob and the police.

Five wayward teenage girls are sent to a reformatory and discover they possess unique powers to battle the ancient demon, Legion, which holds thrall over the sinister institution.