A successful physician and devoted family man, John Dolittle seems to have the world by the tail, until a long suppressed talent he possessed as a child, the ability to communicate with animals is suddenly reawakened with a vengeance! Now every creature within squawking distance wants the good doctor's advice, unleashing an outrageous chain of events that turns his world upside down!

Boog, a domesticated 900lb. Grizzly bear finds himself stranded in the woods 3 days before Open Season. Forced to rely on Elliot, a fast-talking mule deer, the two form an unlikely friendship and must quickly rally other forest animals if they are to form a rag-tag army against the hunters.