When virtually all of the residents of Piedmont, New Mexico, are found dead after the return to Earth of a space satellite, the head of the US Air Force's Project Scoop declares an emergency. A group of eminent scientists led by Dr. Jeremy Stone scramble to a secure laboratory and try to first isolate the life form while determining why two people from Piedmont - an old alcoholic and a six-month-old baby - survived. The scientists methodically study the alien life form unaware that it has already mutated and presents a far greater danger in the lab, which is equipped with a nuclear self-destruct device designed to prevent the escape of dangerous biological agents.

A man struggles with memories of his past, including a wife he cannot remember, in a nightmarish world with no sun and run by beings with telekinetic powers who seek the souls of humans.

Sweethearts Brad and Janet, stuck with a flat tire during a storm, discover the eerie mansion of Dr. Frank-N-Furter, a transvestite scientist. As their innocence is lost, Brad and Janet meet a houseful of wild characters, including a rocking biker and a creepy butler. Through elaborate dances and rock songs, Frank-N-Furter unveils his latest creation: a muscular man named 'Rocky'.